EACS 2015: Hepatitis C Incidence Remains Stable Among HIV-Positive Gay Men in Europe


Researchers have seen no decline in new hepatitis C virus (HCV) infections among HIV-positive men who have sex with men in 16 European CASCADE cohorts, according to a poster presented at the 15th European AIDS Conference last week in Barcelona. However, trends seem to differ between various regions of Europe.

Starting in the early 2000s researchers in the U.K. and elsewhere in Europe began reporting clusters of apparently sexually transmitted acute HCV infection among HIV-positive gay and bisexual men in major cities; similar outbreaks followed in Australia and the U.S. A number of risk factors have been implicated -- including condomless anal sex, fisting, group sex, and non-injection recreational drug use -- but these have not been consistent across studies.

Maria Prins from the University of Amsterdam, who presented the findings, and colleagues with the CASCADE (Concerted Action on SeroConversion to AIDS and Death in Europe) Collaboration estimated trends over time in HCV incidence among HIV-positive gay and bisexual men, and looked at associations between HCV incidence and age, HIV viral load, CD4 T-cell count, and geographical region.

This analysis used data from nearly 6000 men in 16 of the 29 CASCADE  cohorts of HIV seroconverters, or people with well-estimated dates of HIV infection. Cohorts were included if at least half the participating men who have sex with men (MSM) had been tested for hepatitis C using either antibody or HCV RNA tests.

Follow-up time was calculated in 2 ways; the researchers explained that Method 1 would tend to under-estimate HCV incidence, while Method 2 would tend to over-estimate it:

Selected participants were negative for HCV at the start of the follow-up period. The date of HCV infection was estimated as the midpoint between the last negative HCV test and the first positive one.


"Our data show no decline of the HCV incidence after 2007 among HIV-positive MSM, suggesting on-going HCV transmission," the researchers concluded. "In contrast to other studies, no association with CD4 count was observed. Interestingly, higher HIV RNA was associated with higher [HCV] incidence."

In their abstract the investigators suggested that, "Scaling-up preventive measures and HCV testing and treatment with direct-acting antivirals could lead to a decline or stabilization of the HCV incidence among HIV-positive MSM."



DK van Santen on behalf of the CASCADE Collaboration (M Prins presenting). No Decline in Hepatitis C Virus (HCV) Incidence among HIV-positive Men who Have Sex with Men (MSM) within CASCADE: 1990-2014. 15th European AIDS Conference. Barcelona, October 21-24, 2015. Abstract BPD2/7.