EACS 2017: Test-and-Treat Reduces HCV Among Gay Men in Swiss HIV Cohort

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A systematic policy of test-and-treat cured 99% of men who have sex with men with hepatitis C in the Swiss HIV Cohort during an 8-month period and reduced the prevalence of hepatitis C by almost two-thirds, Dominique Braun of the University Hospital, Zurich, reported at the recent 16th European AIDS Conference (EACS 2017) in Milan.

[Produced in collaboration with aidsmap.com]

Braun presented results of the Swiss HCVree trial, a non-randomized study of hepatitis C virus (HCV) testing, treatment, and behavioral counseling designed to eliminate chronic HCV infection among gay and bisexual men with HIV/HCV coinfection in the Swiss HIV Cohort.

The Swiss HIV Cohort has seen a 20-fold increase in the prevalence of HCV among men who have sex with men since 1996, with the greatest increase occurring since 2008, in common with other western European countries.

Reducing onward transmission and prevalence of HCV requires a reduction in the number of people with chronic HCV infection and a reduction in risk behaviors. Chemsex -- especially the use of drugs and sharing of injecting equipment during sex -- and group sex are strongly implicated in the increase in hepatitis C among men who have sex with men.

In an 8-month period between October 2015 and May 2016, all gay and bisexual men in the Swiss HCV Cohort were screened for active HCV infection. Screening identified 177 men with chronic HCV infection (4.8%), of whom 147 had been diagnosed previously; 30 new and previously undiagnosed HCV infections were diagnosed as a result of the screening exercise.

All men with HCV genotype 1 or 4 were offered immediate treatment with a course of grazoprevir/elbasvir (Zepatier) for 12 or 16 weeks depending on baseline resistance, with additional ribavirin for all genotype 1a and 4 patients who previously used pegylated interferon and ribavirin, for previously untreated genotype 1a patients with baseline NS5A resistance mutations, and for genotype 1b patients with prior HCV protease inhibitor experience.

Of the 177 people diagnosed with chronic HCV infection, 122 took part in the study (34 received treatment elsewhere, 11 had a genotype other than 1 or 4, 6 had contraindications for treatment, and the remainder were either lost to follow-up or unwilling to take part in the study).

Men who joined the trial had a median age of 46 years, 88% were white, and all but one were taking antiretroviral therapy. Participants had been diagnosed with HCV for a median of 3 years before joining the study and 79% had F0-F1 stage fibrosis, indicating little liver damage since infection. 6% had F3-F4 stage fibrosis or cirrhosis. The predominant genotypes were 1a (67%) and 4 (26%), with 7% having genotype 1b infection. HCV RNA was relatively low at baseline (865,279 IU/ml).

All participants except one achieved a sustained virological response and were cured of hepatitis C infection. The exception was a previously untreated man with genotype 4 infection who experienced viral rebound after treatment.

Treatment was well tolerated with no serious drug-related adverse events. Drug-related adverse events were reported in 29% of participants and were predominantly fatigue, diarrhea, nausea, and itching.

Preventing Onward Transmission and Reinfection

Sixty-eight men recruited to the study reported condomless sex with non-regular partners. Of these men, 51 agreed to take part in a 4-session behavioral intervention devised by Dunja Nicca of Zurich University that accompanied the treatment phase of the study.

The first session focused on emotional responses to safe sex problems, the second on individualized solutions, the third on developing a personal risk reduction plan, and the fourth session was a reflection on the post-treatment achievement of hepatitis C cure and how to maintain it.

The study found that 65% of men reported condomless anal intercourse as a potential risk factor for acquiring HCV; only 30% reported sharing injecting equipment or equipment for snorting drugs and 29% reported sharing sex toys or fisting as potential risk factors. 40 out of 51 reported drug use, mainly methamphetamine (43%) and GBL or GHB (57%).

The overall completion rate of the behavioral intervention was 90%. No cases of reinfection have been identified to date.

10/31/17

Source

D Braun et al. High SVR12 rates with grazoprevir/elbasvir +/- ribavirin for 12-16 weeks guided by genotypic resistance testing among HIV/HCV coinfected MSM in the Swiss HCVree trial. 16th European AIDS Conference. Milan, October 25-27, 2017. Abstract PS9/4.

 

D Nicca et al. Doing the impossible: an e-health-assisted counselling intervention to reduce risk in HCV-reinfection in men who have sex with men. 16th European AIDS Conference. Milan, October 25-27, 2017. Abstract PE25/24.