HIV/AIDS Topics HIV Disease Progression Non-Progression & Elite Controllers
AIDS 2012: Elite Control and Immune Activation in People with HIV and Hepatitis C
- Details
- Category: Non-Progression & Elite Controllers
- Published on Tuesday, 04 September 2012 00:00
- Written by Liz Highleyman
HIV "elite controllers" in a large women's study were found to still have low-level plasma HIV viral load, which could contribute to persistent immune activation and inflammation, researchers reported at the XIX International AIDS Conference (AIDS 2012) last month in Washington, DC. A series of related studies showed that immune activation was greater in people with HIV and hepatitis C coinfection, and that HIV controllers were also more likely to clear HCV -- though it is not clear why. 
Are HIV Non-Progressors Really Very Slow Progressors?
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- Category: HIV Disease Progression
- Published on Friday, 24 February 2012 00:00
- Written by Liz Highleyman
HIV positive people traditionally classified as long-term non-progressors or viral controllers may in fact progress slowly over time, according to research reported in the February 20, 2012, edition of the open-access journal PLoS ONE. These findings suggest that so-called 
non-progressors may in fact benefit from antiretroviral therapy and could provide clues to aid in development of immune-based therapies.
Genetic Variation in Elite Controllers Linked to Stronger T-cell Response against HIV
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- Category: Non-Progression & Elite Controllers
- Published on Friday, 14 May 2010 13:16
- Written by Press Release
HIV positive people who naturally maintain a very low viral load and do not experience disease progression despite lack of treatment -- known as "elite controllers" -- are likely to carry a gene variation, HLA B57, that is associated with a stronger and more effective immune response against HIV, according to a study published in the May 5, 2010 advance online edition of Nature. When they emerge from the thymus, T-cells from elite controllers appear to be primed to recognize and respond strongly to HIV proteins, but they may also respond more to self proteins, potentially leading to autoimmune reactions.
Cancer-Suppressing Protein May Inhibit HIV in Elite Controllers
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- Category: HIV Basic Science
- Published on Friday, 25 March 2011 01:50
- Written by Press Release
Stepped up expression of the tumor-suppressor protein p21 may help explain how long-term natural HIV controllers keep the virus in check.
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