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CROI 2009: Pre-exposure Prophylaxis Using Oral or Vaginal Tenofovir plus Emtricitabine Protects Monkeys from SIV Infection

Two studies presented at the 16th Conference on Retroviruses and Opportunistic Infections (CROI 2009) this week in Montreal showed that pre-exposure prophylaxis using tenofovir plus emtricitabine -- the 2 drugs in the Truvada fixed-dose combination pill -- protected monkeys from infection with a virus related to HIV. Researchers from the U.S. Centers for Disease Control and Prevention (CDC) demonstrated that these drugs were highly effective in preventing simian immunodeficiency virus infection when administered either orally or in a vaginal microbicide gel.

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PrEP using Tenofovir plus Emtricitabine May Offer Benefits even if HIV Infection Occurs

Animal studies of pre-exposure prophylaxis (PrEP) using tenofovir (Viread), with or without emtricitabine (Emtriva), have produced promising results, and large clinical trials in humans are currently underway. Prevention strategies using antiretroviral drugs are unlikely to be 100% effective, due to variations in efficacy, adherence, and other factors. But there is growing evidence that PrEP may have benefits even for individuals who become infected.

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AIDS 2008: Protective Effect of Circumcision against HIV Infection Is Sustained for Nearly 2 Years

Over the past two years, it has become increasingly clear that adult circumcision helps protect men from acquiring HIV. As previously reported recent studies have shown that circumcision reduced the rate of HIV infection by as much as 60% in high-prevalence countries in Africa. At the XVII International AIDS Conference last week in Mexico City, researchers who conducted one of the pivotal African studies in Kisumu, Kenya, reported follow-up data showing that the benefits appear to be long-lasting.

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How Safe is HIV Serosorting for Men who have Sex with Men?

HIV “serosorting” -- in which HIV positive people have unprotected sex only with other positive people, and negative people only with other negatives -- has been proposed as a strategy for reducing the risk of HIV transmission. The method is far from foolproof, however, requiring that individuals accurately know and honestly convey their current status.

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Agencies Release New Report on State of HIV Prevention Across the U.S.

The Kaiser Family Foundation and the National Alliance of State and Territorial AIDS Directors (NASTAD) has released a new report assessing the status of HIV prevention efforts in the U.S., at a time of increasing budget constraints.

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