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AIDS 2008: Boosted Atazanavir and Lopinavir/ritonavir Have Similar Efficacy, Side Effects Differ across Racial/ethnic Groups

Race-based differences in efficacy and safety have been reported among HIV positive individuals on HAART. However, data on this issue are limited. It is widely known that rates of obesity, diabetes, and the metabolic syndrome are increasing. In addition, studies suggest that certain racial/ethnic groups may be more susceptible to the risks associated with these conditions.

A Comparison of the Single-dose Bioavailability of a Ritonavir Tablet Formulation Compared with the Current Soft Gel Capsule

Ritonavir (Norvir) has been approved by regulatory agencies worldwide and is indicated for use in combination with other antiretroviral agents for the treatment of HIV infection. Due to its cytochrome P450 inhibition properties, ritonavir dosed 100 mg once-daily (QD) to 200 mg twice-daily (BID) is frequently used as a pharmacokinetic enhancer of other antiretrovirals, including protease inhibitors.

AIDS 2008: Attitudes and Perceptions about HIV/AIDS among HIV Patients

Results from an international survey of HIV-positive patients – the largest of its kind conducted to date – were released today at the 17th International AIDS Conference (AIDS 2008). Conducted by the International Association of Physicians in AIDS Care (IAPAC), the survey looked at the attitudes and perceptions of nearly 3000 people living with HIV from 18 countries and shows an urgent global need for improved HIV and AIDS understanding and increased dialog about quality of life.

AIDS 2008: Investigational Next-generation NNRTI Rilpivirine (TMC278) Demonstrates Potent Antiviral Activity at 96 Weeks in Treatment-naive Patients

Tibotec's investigational next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (TMC278) has previously demonstrated good efficacy and tolerability in an international Phase 2b trial of treatment-naive patients through 48 weeks. Investigators presented 96-week follow-up data at the XVII International Conference on AIDS taking place this week in Mexico City.alt

Antiretroviral Therapy is Effective for Injection Drug Users

Injection drug users (IDUs) with HIV can benefit as much from antiretroviral therapy as non-users, according to a study presented Sunday, August 3, in advance of the XVII International AIDS Conference in Mexico City, and published in the August 6 Journal of the American Medical Association.

Growth Hormone Improves Lipodystrophy, but has Detrimental Effect on Blood Glucose

For reasons that are not fully understood, antiretroviral therapy and HIV infection itself are associated with lipodystrophy, a syndrome characterized by visceral adiposity (fat accumulation) and metabolic complications associated with an elevated risk for cardiovascular disease.

Antiretroviral Therapy Does Not Completely Eliminate the Risk of HIV Transmission between Heterosexual Couples

It is well known that by lowering HIV viral load in the blood and genital fluids, effective combination antiretroviral therapy can dramatically lower the risk of transmitting the virus. Some researchers, in fact, have suggested that expanded use of early therapy might significantly reduce HIV incidence on a population basis.