AIDS 2014: Switching ART with Suppressed Viral Load Linked to Treatment Failure

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People who switch away from their initial antiretroviral therapy (ART) regimen when their viral load is undetectable may have a higher likelihood of subsequent virological failure, researchers reported at the 20thInternational AIDS Conference last week in Melbourne. However, the association varied across groups and the researchers suggested their findings may reflect issues such as adherence difficulties or treatment changes due to pregnancy.

Experts recommend starting HIV treatment with a maximally potent combination antiretroviral regimen, especially for people with high viral load. But even in the modern ART era many people wish to switch regimens for the sake of better tolerability or simplicity. Prior studies indicate that about 40% of patients modify their first regimen.

Marina Klein from McGill University in Montreal and colleagues evaluated why people switch first-line regimens for reasons other than inadequate viral suppression -- for example, to reduce side effects or improve convenience -- and the link between switching and subsequent virologic failure. Suppressed viral load was defined as 2 HIV RNA measurements below 50 copies/mL at least 1 month apart; virological failure was defined as viral load above 1000 copies/mL.

This analysis looked at 2807 previously untreated people with HIV in the multi-site Canadian CANOC cohort who started combination ART between 2005 and 2012. Most (87%) were men and the median age was 42 years. The median baseline CD4 T-cell count was 260 cells/mm3, 12% had a history of injection drug use, and 15% were coinfected with hepatitis C virus (HCV).

Results

"Even with modern ART, regimen switch while virologically suppressed was common," with changes presumably due to tolerability, simplification, or to avoid drug interactions, Klein and her colleagues summarized. "Switching from first ART regimen while virologically suppressed was associated with subsequent virologic failure."

Switching ART due to tolerability concerns "might represent specific patient characteristics where ART intolerance is a marker for factors associated with poor adherence" they suggested. They added that the greater likelihood of women switching regimens and experiencing subsequent virological failure might reflect treatment changes related to pregnancy.

However, they noted that this analysis did not actually identify specific reasons for switching or assess the role of adherence. Development of drug resistance has not yet been assessed.

"Regimen switching while virologically suppressed may not be completely benign," the researchers concluded. "Closer follow up among patients switching for non-virologic reasons may be warranted as such switches may serve as a marker for problems with adherence or poorer tolerance of medications."

7/29/14

Reference

M Hull, A Cescon, J Raboud, MK Klein, et al. Switching from first antiretroviral therapy regimen while virologically suppressed is associated with increased risk of subsequent virologic failure.20th International AIDS Conference. Melbourne, July 20-25 2014. Abstract TUAB0103.