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Library of CME Programs

HIV/AIDS CLINICAL TRIALS

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Search for Clinical Trials by State
(TrialSearch@ACRIA - a national database
of currently enrolling studies for HIV/AIDS
and related conditions.)


Open Clinical trials for HIV Infection

Efficacy and Safety of Prezista/ritonavir in Treatment-experienced Patients: 24-week Results of the POWER 1 Study   2/20/07

SMART Data Confirm Risk of CD4-guided Treatment Interruptions   12/08/06

CD4-guided Treatment Interruptions vs Continuous Antiretroviral Therapy in Staccato Trial - 9/01/06

Reasons for Adverse SMART Outcomes Remain Poorly Understood - 8/18/06

Large International Trial Finds Continuous Anti-HIV Therapy Is Greatly Superior to Treatment Interruptions: The SMART Study - 1/20/06

Questions and Answers about the SMART Study - 1/20/06

New Open Clinical Trials for Protease Inhibitors, Entry Inhibitors, Abacavir/Lamivudine vs Emtricitabine/Tenofovir, and Vaccine Adherence in Young IDUs - 10/31/05

Four New HIV Studies Open for Enrollment through ClinicalTrials.gov - 10/24/05


Introduction to Clinical Trials and Frequently Asked Questions

· What is a clinical trial?
· Why participate in a clinical trial?
· Who can participate in a clinical trial?
· What happens during a clinical trial?
· What is informed consent?
· What are the benefits and risks of participating in a clinical trial?
· What are side effects and adverse reactions?
· How is the safety of the participant protected?
· What should people consider before participating in a trial?
· What kind of preparation should a potential participant make for the meeting with the research coordinator or doctor?
· Does a participant continue to work with a primary health care provider while in a trial?
· Can a participant leave a clinical trial after it has begun?
· Where do the ideas for trials come from?
· Who sponsors clinical trials?
· What is a protocol?
· What is a placebo?
· What is a control or control group?
· What are the different types of clinical trials?
· What are the phases of clinical trials?
· What is an "expanded access" protocol?
· (Source: ClinicalTrials.gov)

Glossary of Clinical Trial Terms

· A - Z Dictionary

New HIV/AIDS Clinical Trials Open to Enrollment

ClinicalTrials.gov

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1.

Recruiting

Pediatric Nevirapine Resistance Study
Conditions: AIDS; HIV Infections

2.

Not yet recruiting

Safety of and Immune Response to an HIV Preventive Vaccine (HIV-1 gag DNA Alone or With IL-15 DNA) Given With or Without 3 Different Booster Vaccinations in HIV Uninfected Adults
Condition: HIV Infections

3.

Not yet recruiting

Efficacy of Tenofovir-Emtricitabine and Efavirenz in HIV Infected Patients with Tuberculosis
Conditions: HIV Infections; Tuberculosis

4.

Recruiting

Study of the HIV gp120/NefTat/AS02A Vaccine to Treat Individuals with Chronic HIV-1 Infection on Highly Active Antiretroviral Therapy (HAART)
Condition: HIV Infections

5.

Recruiting

Modafinil for Fatigue in HIV/AIDS
Conditions: HIV Infections; Fatigue; Mental Health

6.

Recruiting

“OK 2004 Study” (Only Kaletra 2004 Study): Study to Evaluate Suspending Nucleosides from Triple-drug Therapy in HIV Subjects
Condition: HIV Infection

7.

Not yet recruiting

Safety of and Immune Response to an Experimental HIV Vaccine (VRC-HIVADV014-00-VP) in HIV Uninfected Adults
Condition: HIV Infections

8.

Recruiting

Safety and Efficacy of an Antibody to CCR5 in Individuals with HIV who Are Not Currently on Antiretroviral Therapy
Condition: HIV Infections

9.

Recruiting

TMC114 with Low Dose Ritonavir (RTV) and Other Antiretrovirals in Experienced HIV-1 Infected Patients with Limited or no Treatment Options
Condition: HIV Infections

10.

Recruiting

Extended Infant Post-exposure Prophylaxis with Antiretrovirals to Reduce Postnatal HIV Transmission
Condition: HIV Infections

11.

Recruiting

Study of the 48-Week Virologic and Immunologic Response to Lopinavir/ritonavir (Kaletra) in HIV Positive Adult Patients
Condition: HIV Infections

12.

Not yet recruiting

Bangkok Tenofovir Study
Condition: HIV Infections

13.

Recruiting

Effectiveness of Nucleoside Supplementation and Substituting Tenofovir Disoproxil Fumarate for Other Drugs in Anti-HIV Regimens in Reversing Fat Loss in HIV Infected Adults
Conditions: HIV Infections; Lipodystrophy; Metabolic Diseases; Nutrition Disorders

14.

Recruiting

The Effect of Low-dose Human Growth Hormone Therapy in HIV Infected Patients
Conditions: HIV Infections; Lipodystrophy

15.

Not yet recruiting

Rosuvastatin versus Pravastatin in HIV Patients Treated with Boosted Protease Inhibitors (PI)
Conditions: Hyperlipidemia; HIV Infections

16.

Not yet recruiting

Efavirenz or Atazanazir/Ritonavir Given with Emtricitabine/Tenofovir Disoproxil Fumarate or Abacavir/Lamivudine in HIV Infected Treatment-Naive Adults
Condition: HIV Infections

17.

Recruiting

Observational Study of Fat Loss in HIV Infected Adults Taking Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
Conditions: HIV Infections; Lipodystrophy; Metabolic Diseases; Nutrition Disorders

18.

Recruiting

Improving HIV Screening by Nurse Rapid Testing, Streamlined Counseling
Conditions: Health Care Quality, Access, and Evaluation; Delivery of Health Care; Immune System Disease; HIV Infections


 


FDA-Approved
HIV and AIDS Treatments

Protease Inhibitors
Agenerase (amprenavir)
Aptivus (tipranavir)
Crixivan (indinavir)
Fortovase (saquinavir soft gel)
Invirase (saquinavir hard gel)
Kaletra (lopinavir/ritronavir)
Lexiva
(Fosamprenavir)
Norvir (ritonavir)
Prezista
(darunavir)
Reyataz (atazanavir)
Viracept
(nelfinavir)

Nucleoside / Nucleotide Reverse Transcriptase Inhibitors

Combivir (AZT+ 3TC)
Epivir (lamivudine; 3TC)
Emtriva (emtricitabine; FTC)
Epzicom (abacavir + lamivudine)
Hivid (zalcitabine; ddC)
Retrovir (zidovudine; AZT)
Trizivir (abacavir + zidovudine +lamivudine)
Truvada  (Tenofovir / Emtricitabine)
Videx (didanosine; ddI)
Viread (tenofovir)
Zerit (stavudine; d4T)
Ziagen (abacavir)


non Nucleoside Reverse Transcriptase Inhibitors
Rescriptor (delavirdine)

Sustiva (efavirenz)
Viramune (nevirapine)

Entry Inhibitors
Fuzeon (enfuvirtide; T-20)

Fixed-dose Combinations
Atripla
(efavirenz + emtricitabine + tenofovir)
Combivir
(retrovir + lamivudine)

Trizivir
(abacavir + zidovudine + lamivudine)
Truvada
(tenofovir + emtricitabine)