Tuberculosis

AIDS 2016: TB 2016 Demands a Global Commitment to End Tuberculosis

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While much of the TB 2016 meeting, held ahead of the 21st International AIDS Conference (AIDS 2016) in Durban, was devoted to the rapidly evolving science in the fight against tuberculosis (TB), the meeting also highlighted the failure of the world, including the international HIV community, to adequately respond to the TB epidemic -- which last year surpassed HIV as the leading infectious cause of death in the world.

[Produced in collaboration with Aidsmap.com]

This has led to a series of calls for a paradigm shift to move beyond TB control to actually ending TB. However, as Stephen Lewis of AIDS-Free World said in a keynote address on the final day of the pre-conference, "this room is filled with principled advocates and activists who would move heaven and earth to defeat this disease, but the collective efforts are compromised by indifference in high places, by an absence of political leadership, and by strangulated shortfalls in resources.”

So Little Progress Over So Much Time

"For many countries, including mine, TB and HIV are 2 sides of the same coin," South African Minister of Health Aaron Motsoaledi said in the inaugural plenary address at TB 2016, the first time the International AIDS Society has organized an AIDS conference pre-meeting devoted to tuberculosis. "We will not end AIDS without ending TB. We will either succeed or fail together and so working alone is not an option."

The minister paraphrased former South African President Nelson Mandela’s clarion call in 2004 to fight TB as well as AIDS -- but as José-Luis Castro, executive director of the International Union Against Tuberculosis and Lung Disease pointed out in a talk during the same plenary, that despite some advances, relatively little has changed. Here we are 12 years later, and:

One out of every 3 people on the planet is infected with Mycobacterium tuberculosis, the bacterium that causes TB, though only around 10% will progress to active disease. Even so, over 9 million people develop TB each year, and 3 million of those people go undiagnosed and never receive treatment; 4400 people die each day from TB.

"Together 7100 people die of HIV and TB every day," said Eric Goosby, the UN Special Envoy for TB. "We have a disease that we have known how to prevent, diagnose, and treat for over 40 years, and have been unable to put delivery systems in place that effectively identify, enter, and retain people in care for a 6-month period of time.”

"As TB and HIV activists, we were calling out to have ambitious goals and here we are," said Thokozile Phumizile of Facilitators of Community Transformation (FACT), who has worked extensively in TB/HIV. Nevertheless, she was angry that there continue to be so many deaths. She reminded the audience that there are people attached to those statistics.

"We are talking about our brothers, our sisters, our uncles. We are talking about people who are mentors, people who are parents, and children, who are the future," she said. "I feel neglected, I feel backstabbed because I’ve seen people in my family dying of TB…[even though they were] taking antiretrovirals."

The global indifference to TB can be traced back decades -- to about the time when improvements in treatment, living, and health standards made the disease rare in industrialized countries -- and it became a disease of the most vulnerable and poor populations in resource-constrained countries. As a consequence, TB science became a backwater.

In order to effect recent calls now to end TB either by 2030 (in the UN’s Sustainable Development Goals) or by 2035 in WHO’s Global Strategy to End TB, new prevention, diagnostic and treatment tools will be needed. However, funding for TB research has long lagged behind HIV, as illustrated by this comparison of drug development adapted from the Treatment Action Group's HIV and TB Pipeline Report.

 

HIV

TB

Global burden

36.7 million people living with HIV

2.1 million new cases p.a (2015)

9.6 million new cases p.a (2014)

Money spent on new drug research

USD 2.6 billion (2011)

USD 243 million (2014)

Number of new drugs approved by US FDA since 1987

>37 drugs or drug combinations

2 drugs*

Number of clinical trials behind some of the newest drugs

Dolutegravir, 61 trials

Delamanid, 6 trials

*Delamanid not yet FDA-approved [nor is it available in South Africa, despite the fact that many of the drugs trials were conducted there]

Similarly, Motsoaledi pointed out that there has been a dramatic increase in people living with HIV on treatments since the year 2000 -- with 17 million people receiving antiretroviral therapy compared to 1 million in the year 2000 (which represents a 1600% increase). However, he continued, "there was only a 65% increase in people infected with TB receiving treatment over the same period of time. And the rise in drug resistance, especially antimicrobial resistance, has further made complex which is already a difficult situation."

"If we continue on our current pace and trajectory, it will not be possible to end TB until 2180. We want the world to respond with the same sense of urgency, if not more, demonstrated to recent outbreaks of Ebola and the Zika virus," the minister added.

A Call to Action

Stephen Lewis explored the funding and leadership gap in a little more detail in a keynote address on the final day of the pre-conference -- and had some interesting ideas about how to better leverage resources.

"TB is overwhelmingly funded by the Global Fund; without it, there would be a vacant pipeline," he said. "As has been noted, some 77% of funding for TB in Africa comes from the Global Fund. However, only about 17% of the fund’s resources go to TB, while 53% goes to HIV and 30% to malaria. Tuberculosis is the impoverished cousin…one and a half million [dead from TB] annually, and not a single death necessary."

If the Global Fund is not replenished this September, TB will be hard hit.

In addition, the Global Plan to End TB will require $13 billion a year in funding until 2030 -- but the current funding levels are one-half of that -- and as Lewis pointed out, "the replenishment target for the Global Fund is $13 billion over 3 years."

Lewis also highlighted how the leading organizations in the fight to end TB are not powerful international entities, rooted in the United Nations, with vast budgets at hand -- unlike UNAIDS.

"Wouldn’t you say -- I don’t think this is intellectual innocence on my part -- that UNAIDS is a logical repository to drive the response to tuberculosis; if the two are stitched so relentlessly together, and TB is now a greater killer than AIDS, would you not think that the entity charged with the international institutional responsibility for AIDS, would be the protagonist in the fight against TB?," he asked.

Lewis conceded that it might be difficult to introduce this change into UNAIDS because of its current structure within the UN and its governance. However, he recommended an alternative -- the United Nations Development Program (UNDP), which is the largest and best-resourced UN agency, is in virtually every country, and has strong relations with the government of every country.

"If UNDP were to decide to exercise significant leadership on TB, it could make a stunning impact," he said, pointing out that UNDP has already been involved with TB in some countries.

He also believes it might be possible to set up a new financial machine behind the TB response. He reminded the audience that an old ally, Jim Kim, president of the World Bank, had focused significantly on TB from Russia to Peru in his early days at Partners in Health.

In fact, Lewis reported that Kim had told him that he’d be willing to sit down with a representative group "to discuss, concretely, innovative forms of financing to fund TB."

More political pressure will also clearly be needed. Minister Motsoaledi places great hope in the Global TB Caucus -- a body of members of parliament (1004 members from 126 countries) seeking to address TB in their own countries, regions, and globally. Motsoaledi, who co-chairs the group, said that it had formally endorsed the Global Plan to end TB last year.

One of their first orders of business ought to be acting upon a Stop TB Partnership and MSF petition being circulated at the conference called Step Up for TB: Sign on the Dotted Line. It demands that all countries upgrade their responses to TB to utilize currently available tools, including the latest diagnostic technology, medicines, and treatment guidelines within 500 days.

In addition, as the Union’s Castro stressed, countries also need to address "the root causes of the TB/HIV epidemic: poverty, malnutrition, poor housing conditions, injustices from stigma to gender discrimination, and the denial of basic human rights."

Leveraging a human right to health approach may be the best way to move the agenda forward, according to Mike Frick of TAG, who quoted Partners in Health’s Paul Farmer in his concluding remarks.

"What we need…is an agenda for research and action grounded in the struggle for social and economic rights, an agenda suited to public health and medicine, whose central contributions to future progress in human rights will be linked to the equitable distribution of the fruits of scientific advancement," he said.

And at the close of the conference, a delegation of African parliamentarians said that they were indeed committed to fight for better sanitation and urban policies that benefit the poor, and a human rights approach to healthcare.

Time will tell if this is just MOSOTOS (More Of the Same Old Talk, Opinions and Speeches), or if it will indeed be the change needed to truly end TB and AIDS. But, as Castro concluded, "If we choose to change we have a shot of beating two of the worst epidemics that humanity has known."

7/19/16

Reference

TB 2016. 21st International AIDS Conference. Durban, July 16-17, 2016.