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Phenotype
/ Virtual Phenotype Resistance Testing
 Drug
Resistance Testing in HIV-1 Infection - Phenotype Assay
By
Daniel R. Kuritzkes, MD
Genotype
Resistance Testing
Replication Capacity Testing
| PHENOTYPIC
ASSAY: A procedure whereby sample DNA of a patient's HIV is tested against
various antiretroviral drugs to see if the virus is susceptible or resistant to
these drugs. See Resistance. |
Transmitted
Drug Resistance Does Not Have a Long-term Impact on the Natural History of HIV
infection or Response to First-line Therapy - 1/27/06
Reduced
Susceptibility to Protease Inhibitors (PI) in the Absence of Primary PI Resistance-Associated
Mutations
- 6/27/05
Susceptibility
Measurements Using Resistance Test Vectors with or without Patient-Derived C-terminus
of RT, RNAseH and Integrase Are Largely Concordant
- 6/27/05
Determination
of Phenotypic Clinical Cutoffs for Atazanavir and Atazanavir/Ritonavir - 6/15/05
Reduced
Susceptibility to Protease Inhibitors (PI) in the Absence of Primary PI Resistance-associated
Mutations - 6/15/05
Accuracy,
Precision and Consistency of HIV-1 Genotype Interpretation by Experts - 6/13/05
Salvage
Therapy Guided by Rules-based or Phenotype-driven HIV Genotypic Drug Resistance
Interpretation with or without Concentration-controlled Intervention - 6/13/05
Drug
Concentration Control Provides No Apparent Help in HIV Salvage Therapy
- 6/08/05
Study
Finds PhenoSense Assay More Precise Than the Antivirogram Assay and Superior
at Detecting Resistance to Abacavir, Didanosine and Stavudine
- 3/28/05
Predicting
the Response to Didanosine Using Phenotypic Susceptibility - 2/25/05
ViroLogic
Assays Characterize and Identify Potential Treatments for Virulent Multi-Drug
Resistant Strain of HIV - 2/16/05
Updated
European Recommendations for the Clinical Use of HIV Drug Resistance Testing
-
1/28/05
Selection
of Antiretroviral Therapy Guided by Genotypic or Phenotypic Resistance
Testing
- 12/10/04
Meta-analysis Shows Limited
Benefit of Drug Resistance Testing in Treatment-experienced Patients - 11/24/04
Evolution
of Genotypic and Phenotypic Resistance to Enfuvirtide in HIV Patients Experiencing
Prolonged Virologic Failure -
07/26/04
Comparison
of Original and Updated Genotypic and Phenotypic Susceptibility Algorithms
for Treatment-Experienced Patients - 06/23/04
Impact
of Residue 50 Substitutions on Phenotypic Susceptibility to Protease Inhibitors - 06/23/04
Sensitivity
of Phenotypic Analyses for Detection of K65R or M184V in Mixtures with Wild-type
HIV - 06/21/04
Salvage Therapy with Lopinavir/Ritonavir
Leads to Decrease in HIV Viral Load and to Phenotypic Change in HIV Vertically
infected Children -
4/19/04
Genotypic and
Phenotypic Predictors of the Magnitude of Response to Tenofovir in Treatment-experienced
HIV Patients - 04/09/04
Impact of Drug Levels and Baseline Genotype and Phenotype
on the Virologic Response to Amprenavir/Ritonavir-based Salvage Regimens -
04/02/04
Natural Variation of Drug Susceptibility
in Wild-type HIV-1 - 03/24/04
Does Use of Resistance Testing Improve Long-term
Virologic Outcomes in HIV Patients? - 03/03/04
High-Level
Resistance to HIV-1 NNRTIs in the Absence of Known Resistance Mutations
09/15/03
ERA
Trial: Does a Phenotype Add to a Genotype in Patients with Limited
Treatment
Options?
07/18/03
Virtual
Phenotyping Is Helpful in HIV Drug Resistance Testing
04/25/03
Phenotyping and NNRTI
Hypersusceptibility Are Predictive of Successful Treatment
04/21/03
Library
of Abstracts, Posters and Slides on Resistance Testing
- 10th
CROI
02/19/03
Data from
Phenotyping Studies at the Barcelona AIDS Conference: Part II
08/14/02
Review of Phenotypic
Resistance Testing Data Presented at the XI International HIV Drug Resistance
Workshop (July 2-5, 2002) PhenoSense
Drug Resistance Testing and an HIV Entry Assay: Abstracts from the XIV International
AIDS Conference (July
7-12, 2002)
HIV
Patients with Drug-Resistant Virus May Benefit from Resistance Testing Prior to
Starting Treatment
07/05/02
Phenotype
Testing Urged When Switching HIV-1 Positive Patients from Agenerase (Amprenavir)
05/24/02
9th Annual Retrovirus
A Review of Selected Data on Phenotypic HIV Drug
Resistance Testing
03/08/02
9th
Annual Retrovirus
Library of Abstracts on HIV Drug Resistance Testing
Part I: Phenotyping
03/08/02
New
Data on HIV Drug Resitance from the 41st ICAAC
02/25/02
Library of Abstracts
on HIV Drug Resistance Testing at the 9th CROI, Part I: Phenotyping
(February 24 - 28,
2002)
Abstracts
on ViroLogic Assays Presented at 41st ICAAC
12/22/01
ViroLogic
Launches Combination HIV Drug Resistance Test To Provide Both Phenotypic
and Genotypic Information on a Single Report
11/19/01
ViroLogic
and Roche Expand Agreement on Use of Resistance Testing for New Anti-HIV Drugs
T-20 and T-1249
11/19/01
Data
Support Use of "Virtual Phenotype" in Heavily Treatment-Experienced
Patients
6/11/01
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