Teno Viruses More Common among HIV/HCV Coinfected People, Linked to Greater
Liver Inflammation and Fibrosis
A common but little known set of viruses -- torque teno virus
(TTV) and torque teno mini virus (TTMV) -- occur more often
in HIV/HCV coinfected individuals than in healthy blood donors,
and have been linked to worse liver inflammation and fibrosis
progression, according to a poster presented at the 50th Interscience
Conference on Antimicrobial Agents and Chemotherapy (ICAAC
2010) last week in Boston.
TTVM are small, genetically variable DNA viruses that are ubiquitous
in humans worldwide. They have not been definitively shown to be the
cause of any particular diseases, but some research suggests a potential
link with liver disease, cancer, and autoimmune conditions such as lupus.
M. Garcia-Alvarez from Instituto de Salud Carlos III in Madrid and colleagues
sought to learn more about the prevalence and clinical significance
of TTV and TTMV in HIV/HCV
conducted a cross-sectional study that included 245 coinfected patients
who underwent liver biopsy prior to starting hepatitis
C treatment, as well as 100 healthy HIV and HCV negative blood donors.
prevalence of both TTV (94% vs 83%; P = 0.002) and TTMV (95% vs
72%; P < 0.001) was significantly higher among HIV/HCV coinfected
patients compared with healthy blood donors.
addition, among people who carried TTV and/or TTMV, viral loads
of these 2 viruses were higher in HIV/HCV coinfected people compared
with the blood donors:
about 7000 vs about 150 copies/mL, respectively (P < 0.001);
about 900 vs about 25 copies/mL, respectively (P < 0.001).
the coinfected patients, there was an association between higher
levels of TTV and/or TTMV and worse liver disease.
patients with TTV viral load at the 75th percentile or above (about
600 copies/mL) had more than twice the risk of severe necro-inflammatory
activity (A3 or higher) and advanced fibrosis
(F3 or higher) (odds ratios 2.42 and 2.29, respectively).
with TTMV viral load at the 75th percentile or above (about 75 copies/mL)
were significantly less likely to have absent necro-inflammatory
activity (< A1) and no significant fibrosis (< F1) (odds ratios
0.41 and 0.36, respectively).
found a high prevalence of both TTV and TTMV infections in HIV/HCV positive
patients," the researchers concluded. "We also found an association
between higher viral load of TT viruses and higher activity grades and
fibrosis stages in liver biopsies."
work should be done to assess the contribution of TT viruses to liver
disease progression in HIV/HCV positive patients," they recommended.
affiliations: Inst. de Salud Carlos III, Majadahonda, Madrid, Spain;
Hosp. Gen. Universitario Gregorio Maranon, Madrid, Spain.
M Garcia-Alvarez, J Berenguer, P Miralles, and others. Torque Teno
Virus (TTV) and Torque Teno Mini Virus (TTMV) in HIV/HCV Co-Infected
Patients: Prevalence and Role in Liver Disease. 50th Interscience Conference
on Antimicrobial Agents and Chemotherapy (ICAAC 2010). Boston, September
12-15, 2010. (Abstract