Higher CD4 Cell Count Linked to Hepatitis B Surface Antigen Loss in HIV/HBV Coinfected Patients

		SUMMARY: Loss of hepatitis B surface antigen (HBsAg) -- an indicator of hepatitis B virus (HBV) control by the immune system or successful treatment -- is more likely to occur in HIV/HBV coinfected individuals who maintain a high CD4 cell count, according to a retrospective analysis reported in the March 7, 2010 World Journal of Gastroenterology. This finding supports the recommendation that HIV/HBV coinfected patients may benefit from earlier initiation of antiretroviral therapy (ART), while immune function is still relatively intact.

Below is the text of a press release from the World Journal of Gastroenterology describing the study and its findings.

Predictors of Loss of Hepatitis B Surface Antigen
in Patients Co-Infected with HIV and HBV

March 30, 2010 -- Co-infection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) poses a treatment challenge. In Western Europe and the United States, chronic HBV infection has been found in 6%-14% of HIV positive patients and this co-infection is well known to be associated with increased liver-related morbidity and mortality. However, factors associated with HBV surface antigen (HBsAg) loss in HIV and HBV co-infected patients remain unclear.

A research article to be published on March 7, 2010 in the World Journal of Gastroenterology addresses this question. The research team from St. Luke's-Roosevelt Hospital Center, New York City, USA, performed a retrospective chart review of 5681 patients followed up at St. Luke's-Roosevelt Hospital HIV clinic (the Center for Comprehensive Care) in New York City from Jan 1999 to May 2007. HIV and HBV co-infection was defined as positive HIV infection and HBsAg serology.

The authors compared patients with HBsAg loss to the rest of the cohort at baseline and at time of loss of HBsAg. Clinical and laboratory parameters including baseline and follow-up HIV viral loads, CD4 cell counts, alanine aminotransferase (ALT) levels, HCV co-infection, demographics, and duration of anti-HBV therapy were analyzed to determine factors associated with loss of HBsAg.

Of the 5681 HIV infected patients in the cohort, 355 patients were HIV and HBV co-infected and were evaluated. Of these, 226 patients with more than 12 months follow-up were included in the further analysis to better estimate factors associated with loss of HBsAg in the long-term follow-up. The patients were observed for a mean duration of 45.6 months (range, 20.8 - 61.1 months). During the follow-up period, 21 patients lost HBsAg.

In the univariate analysis, baseline CD4 cell count was associated with loss of HBsAg (P = 0.052). Other factors, including baseline ALT, presence of hepatitis C virus co-infection, baseline HIV viral load, HIV viral load at end of follow-up, CD4 cell count at end of follow-up, CD4 cell count gain, and treatment with dually active antiretrovirals were not related to loss of HBsAg.

Cox regression analysis revealed that baseline CD4 cell count > 500 cells/mm3 was associated with loss of HBsAg.

The study showed an interesting association of HBsAg loss in HIV-HBV co-infected patients with higher CD4 cell count, suggesting that T-cell cytolytic activity against HBV may still be effective in clearing HBV infection.

Center for Comprehensive Care, Division of Infectious Diseases, St. Luke's-Roosevelt Hospital Center, New York, NY; Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA; Center for Comprehensive Care, St. Luke's-Roosevelt Hospital Center, New York, NY.

4/13/10

Reference
G Psevdos, JH Kim, JS Suh, and VL Sharp. Predictors of loss of hepatitis B surface antigen in HIV-infected patients. World Journal of Gastroenterology 16(9): 1093-1096 (Free full text). March 7, 2010.
Other Source

World Journal of Gastroenterology. Predictors of loss of hepatitis B surface antigen in patients co-infected with HIV and HBV. Press release. March 30, 2010.