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Rilpivirine (TMC-278)

What is the most important information I should know about rilpivirine?

Rilpivirine is an experimental non-nucleoside reverse transcriptase inhibitor (NNRTI) being developed by Tibotec, a biotechnology company in Belgium. It has not yet been evaluated by the U.S. Food and Drug Administration (FDA) for use by people living with HIV.

What is rilpivirine?

Rilpivirine is in a category of HIV medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs). Rilpivirine prevents HIV from entering the nucleus of healthy T-cells. This prevents the cells from producing new virus and decreases the amount of virus in the body.

Long-acting TMC278, a parenteral depot formulation delivering sustained NNRTI plasma concentrations in preclinical and clinical settings  - 2/20/08

Rilpivirine (TMC278) Causes Less Blood Lipid Elevation than Efavirenz (Sustiva)   - 8/24/07

TMC278 Demonstrates Equally Potent and Durable Efficacy, Less Rash, Better Lipid Profile, and Fewer Nervous System Effects than Efavirenz  - 3/06/07


48-week primary analysis of trial TMC278-C204: TMC278 demonstrates potent and sustained efficacy in ARV-naïve patients
A Pozniak and others. Poster 556
(PowerPoint).

 



 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 



FDA-Approved Treatments
for HIV/AIDS


Experimental Treatments
for HIV/AIDS