IAS 2009: Tenofovir/emtricitabine (Truvada) plus Lopinavir/ritonavir (Kaletra) or Raltegravir (Isentress) Work Well for Post-exposure Prophylaxis

Post-exposure prophylaxis (PEP) regimens consisting of tenofovir/emtricitabine (Truvada) plus lopinavir/ritonavir (Kaletra) or raltegravir (Isentress) prevent HIV infection as well as zidovudine/lamivudine (Combivir) regimens, but with fewer side effects, according to 2 presentations at the recent 5th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention (IAS 2009) in Cape Town, South Africa.

Read more:

IAS 2009: Vitamin D Deficiency is Common among HIV Positive People and Is Associated with NNRTI Use, Black Race, and Smoking

Two research teams presented study findings at the recent 5th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention (IAS 2009) in Cape Town, South Africa, showing that inadequate vitamin D levels are highly prevalent among people with HIV, and individuals taking efavirenz (Sustiva) are at particularly high risk

Read more:

IAS 2009: ARIES Trial Shows Unboosted Atazanavir (Reyataz) Maintains Viral Suppression as well as Boosted Drug

The protease inhibitor atazanavir (Reyataz), taken with abacavir/lamivudine (Epzicom coformulation), was as likely to keep viral load undetectable after initial suppression as the same combination plus a boosting dose of ritonavir, researchers reported at the 5th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention (IAS 2009) last month in Cape Town, South Africa. The unboosted regimen, however, was less likely to cause cholesterol and triglyceride elevations.

Read more:

IAS 2009: Lipid and Glucose Changes Related to Boosted Darunavir (Prezista) in Children and Adolescents with HIV: DELPHI Study

Ritonavir-boosted darunavir (Prezista) was effective and generally well-tolerated at week 48 among treatment-experienced children and adolescents with HIV in the DELPHI study, according to a presentation at the 5th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention (IAS 2009) last month in Cape Town, South Africa. No change was seen in glucose levels after starting the drug, and triglyceride levels decreased significantly.

Read more:

IAS 2009: HIV/HCV Coinfected Patients Treated with NRTI-Sparing Antiretroviral Regimens Respond Better to Pegylated Interferon plus Ribavirin

HIV/HCV coinfected patients treated with pegylated interferon plus ribavirin achieved a sustained virological (SVR) rate of 54% -- the same as HIV negative individuals -- and sustained response was more likely in patients who did not take a nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) as part of their combination antiretroviral regimen.

Read more: