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Hepatitis B

7. Tenofovir Alafenamide Approved for Hepatitis B

In November the U.S. Food and Drug Administration (FDA) approved tenofovir alafenamide (TAF) for the treatment of hepatitis B, offering a new option that is easier on the bones and kidneys than the older version of tenofovir.

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AASLD 2016: Nivolumab Shows Good Safety and Promising Response Rates in Liver Cancer Study

Nivolumab (Opdivo), an antibody that blocks the PD-1 receptor and restores T-cell anti-tumor activity, appeared safe and was associated with disease control and stabilization in a Phase 1/2 study of patients with hepatocellular carcinoma, according to late-breaking results from the CheckMate 040 study presented at the AASLD Liver Meeting last month in Boston.

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AASLD 2016: Tenofovir Alafenamide Approved for Hepatitis B, Works Well with Less Effect on Bones

Tenofovir alafenamide (TAF), a new lower-dose pro-drug, matches the older tenofovir disoproxil fumarate (TDF) for antiviral activity against hepatitis B virus but causes less bone mineral loss, according to a report at the AASLD Liver Meeting this week in Boston. The U.S. Food and Drug Administration last week approved stand-alone TAF for hepatitis B treatment.

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AASLD 2016: GS-4774 Therapeutic Vaccine Shows Little Efficacy in People with Hepatitis B

An experimental immune-based therapy for chronic hepatitis B combined with tenofovir was safe and well-tolerated, but did not lead to greater reductions in hepatitis B surface antigen (HBsAg) than the antiviral alone, according to a study reported at the AASLD Liver Meeting this month in Boston.

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FDA Warns of HBV Reactivation Risk After Starting Hepatitis C Medications

The U.S. Food and Drug Administration (FDA) this week issued a new safety warning about the risk of hepatitis B virus (HBV) reactivation in people treated with direct-acting antivirals (DAAs) for hepatitis C. In a few cases HBV reactivation has led to serious liver problems or death. The FDA will now require a boxed warning on package labels for all DAAs. The caution applies to people who currently have chronic hepatitis B and those who previously cleared HBV spontaneously or with treatment.

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AASLD 2016: Nucleic Acid Polymers Reduce HBsAg Levels and Improve Control of Hepatitis B Virus

The nucleic acid polymers REP 2139 and REP 2165 led to hepatitis B surface antigen (HBsAg) reduction or clearance when combined with tenofovir and pegylated interferon, according to early results from a small study presented as a late-breaker at the AASLD Liver Meeting this month in Boston. This combination may potentially enable functional control of hepatitis B if confirmed in larger studies.

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Hepatitis B Testing Should Be Done Before and During Hepatitis C Treatment

People considering treatment for hepatitis C should first be tested for hepatitis B virus (HBV) and monitored throughout therapy, as successful elimination of hepatitis C virus (HCV) can reactivate HBV and potentially worsen liver disease, according to recent updates to American and European hepatitis C treatment guidelines.

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Coverage of the 2016 AASLD Liver Meeting

HIVandHepatitis.com coverage of the 2016 American Association for the Study of Liver Diseases (AASLD) Liver Meeting in Boston, November 11-15, 2016.

Conference highlights include direct-acting antiviral therapy for difficult-to-treat people with hepatitis C, novel hepatitis B agents, complications of viral hepatitis, and NAFLD/NASH.

Full listing by topic

Liver Meeting 2016 website

11/20/16

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Viral Hepatitis Is Now A Major Global Cause of Death, Exceeding HIV and TB

Hepatitis B and C have become leading causes of death and disability worldwide, as other major communicable diseases such as HIV/AIDS, malaria, and tuberculosis (TB) have come under better control, according to an analysis published in the July 8 online edition of The Lancet.

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