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AIDS 2014: Australian Bone Marrow Transplant Patients Show No Detectable HIV

An additional 2 people with long-term HIV infection have no evidence of infectious virus or viral genetic material following bone marrow stem cell transplants to treat leukemia or lymphoma, researchers reported at the 20th International AIDS Conference last month in Melbourne. While these individuals remain on antiretroviral therapy (ART) and therefore cannot be considered functionally cured, they offer further evidence that HIV may be controlled off ART in some cases.

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Broadly Neutralizing Antibodies May Prevent Reservoir HIV from Entering T-Cells

HIV-specific broadly neutralizing antibodies may be able to prevent virus emerging from latent reservoir sites from entering CD4 T-cells, as well as suppressing viral replication if HIV does manage to get in, according to NIAID research published in the August 25 advance edition of Proceedings of the National Academy of Sciences.

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AIDS 2014: Female Condoms for HIV Prevention [VIDEO]

While biomedical HIV prevention was a key theme of the recent 20th International AIDS Conference in Melbourne, other approaches remain important including wider access to internal or female condoms. Designed to be worn inside the body, female condoms can give women more control in protecting themselves against HIV.

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AIDS 2014: Only Half of People Who Start HIV Post-exposure Prophylaxis Complete the Course

There are significant losses at each step of the post-exposure prophylaxis (PEP) "treatment cascade," according to a systematic review and meta-analysis of 97 studies presented to the 20th International AIDS Conference last month in Melbourne. The problems with uptake, adherence, and completion point to a need for a simplified approach, researchers said.

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AIDS 2014: Single-tablet HIV Regimens Not Necessarily More Durable

Antiretroviral therapy (ART) regimens consisting of 1 pill taken once-daily -- known as single-tablet regimens -- were not associated with a longer time to treatment discontinuation when compared to some other modern, well-tolerated regimens that involve more pills or twice-daily dosing, according to a study presented at the 20th International AIDS Conference last month in Melbourne.

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AIDS 2014: Novel Techniques Probed in HIV Cure Research

A pair of presentations at the 20th International AIDS Conference in Melbourne described new pathways being explored in the search for either a permanent cure for HIV or for longer-acting drugs. In one study, 2 artificial genes that cause cells to generate antiviral entry inhibitors produced significant inhibition of cellular infection. In the other, a technique that is the exact opposite of the much-explored "kick and kill" strategy (which uses drugs to activate cells latently infected with HIV) used an artificial gene fragment to maintain latently infected cells in a locked-down state that resisted strong immune stimulation.

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Gut Microorganisms May Play a Role in HIV Response

Antibodies in people with HIV that target the virus's gp41 envelope protein can cross-react with normal intestinal bacteria, helping to explain why these antibodies are not effective in controlling HIV infection, according to research published in the August 13 edition of Cell Host & Microbe.

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