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Pre-exposure Prophylaxis (PrEP)

CROI 2016: Dose-Finding Trials of Antibody-Based Drugs for HIV Prevention To Start Soon

The next generation of pre-exposure prophylaxis (PrEP), and even HIV treatment, may consist of antibodies that could be given as an intravenous infusion or an injection into muscle, according to 2 presenters at the Conference on Retroviruses and Opportunistic Infections (CROI 2016)last month in Boston.

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Study Sheds Light on Why Women Need More Truvada for HIV PrEP

Tenofovir and emtricitabine -- the drugs in the Truvada combination pill used for HIV pre-exposure prophylaxis (PrEP) -- reach higher levels in rectal compared with female genital tract tissue, and the rectum also contains fewer of the natural DNA building blocks that compete with the drugs, according to research published in the February 24 advance online edition of the Journal of Infectious Diseases.

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CROI 2016: High STI Rates Among Gay Men on PrEP Supports More Frequent Monitoring

Participants taking tenofovir/emtricitabine (Truvada) for pre-exposure prophylaxis (PrEP) continued to have high rates of sexually transmitted infections (STIs) in 2 U.S. PrEP demonstration projects, according to a pair of reports at the Conference on Retroviruses and Opportunistic Infections (CROI 2016)last month in Boston. Semi-annual STI testing missed many cases, leading researchers to suggest that gay men on PrEP could benefit from screening every 3 months.

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England's PrEP Policy in Disarray After National Health Service Turnaround

Activists, individuals at risk of HIV, and clinicians have reacted with anger to an official U-turn on provision of HIV pre-exposure prophylaxis (PrEP) in England, where National Health Service (NHS) officials have refused to allow a draft policy on PrEP to go forward for further consideration. "By denying full availability of PrEP we are failing those who are at risk of HIV," commented Ian Green of Terrence Higgins Trust, a leading U.K. HIV/AIDS organization. "PrEP has already been approved in the U.S., Kenya, South Africa, Israel, Canada, and France. And yet, our own government refuses to take responsibility for PrEP."

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CROI 2016: Rapid Rise in PrEP Awareness in U.S. Gay Men, But Only 5% Have Used PrEP

Large internet surveys of American gay men show that the proportion who have heard of pre-exposure prophylaxis (PrEP) jumped from 45% in 2012 to 68% in 2015, with around half of men willing to consider using PrEP -- but that actual usage is far lower and remains concentrated in a few key urban areas where public health authorities have facilitated its uptake, according to data presented at the recent Conference on Retroviruses and Opportunistic Infections (CROI 2016)in Boston.

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