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HIV-Related Conditions

ASCO: Characteristics and Disparities of Care for HIV+ People with Lung Cancer

HIV positive people with lung cancer are diagnosed at a younger age and have shorter survival than HIV negative people, on average, suggesting that screening should perhaps be started earlier, according to studies presented at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO) this month in Chicago.

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People with HIV Are at Higher Risk for Cancers Linked to Smoking, Viruses

People with HIV appeared to have a higher overall rate of cancer in a large Danish study, but the difference was only significant for malignancies caused by smoking or other viruses, including lung cancer, anal cancer, and liver cancer. A related U.S. study found the rate of prostate cancer was actually lower among HIV positive men.

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CROI 2014: Heart Attack Link to Abacavir Persists in D:A:D Study

The nucleoside reverse transcriptase inhibitor abacavir (Ziagen, also in Epzicom or Kivexa) continues to be associated with a near-doubling of the risk of heart attack, according to the latest update from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) study, presented to the 21st Conference on Retroviruses and Opportunistic Infections (CROI) this month in Boston.

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ASCO: HCV Reactivation, Brain Involvement Do Not Worsen Lymphoma Survival for People with HIV

Reactivation of hepatitis C was common among HIV positive people with lymphoma, but did not appear to lead to worse outcomes or decreased survival, according to a study presented at the 50th American Society of Clinical Oncology (ASCO) meeting this week in Chicago. A related study found that having central nervous system involvement at the time of diagnosis did not decrease survival of people with AIDS-related lymphoma.

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CROI 2014: Newborns Exposed to Tenofovir Have Lower Bone Content [VIDEO]

Infants born to women who took tenofovir during pregnancy had significantly lower bone mineral content than babies who were not exposed, according to study findings reported at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this month in Boston.

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Rilpivirine Is Associated with Less Blood Fat Elevation than Efavirenz

People with HIV who started first-line treatment with a regimen containing rilpivirine (Edurant, also in the Complera coformulation) had smaller blood lipid increases and were less likely to have abnormal levels than those who started on efavirenz (Sustiva, also in the Atripla coformulation), according to 2-year data from the ECHO and THRIVE trials published in the April 11 online edition of Clinical Infectious Diseases.

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CROI 2014: People with HIV More Likely to Die of Many Common Cancers

People with HIV are more likely to die from many common cancers than the rest of the U.S. population, according to a large comparative study presented at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this month in Boston.

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People with HIV Have Higher Bone Fracture Risk in Danish Study

Being HIV positive was associated with a nearly 3-fold greater likelihood of bone fractures overall -- and a 9-fold higher risk of hip and spine fractures -- compared with HIV negative people, according to results from a large Danish population study described in the May 1 Journal of Acquired Immune Deficiency Syndromes.

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CROI 2014: Heart Attack Risk May Be Falling for People with HIV -- But Not for Women

A number of studies at last week’s 21st Conference on Retroviruses and Opportunistic Infections in Boston examined whether people with HIV have an elevated risk of heart attack and other manifestations of cardiovascular disease  (CVD). They came to different conclusions about whether having HIV is in itself a cardiovascular risk factor.

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People with HIV Have Higher Risk of Melanoma Skin Cancer

People with HIV -- especially those with light skin -- continue to have a significantly increased risk of developing melanoma in the era of highly effective antiretroviral therapy, and should protect themselves from the sun, according to a meta-analysis published in the April 16 edition of the open-access journal PLoS ONE.

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Coverage of the 2014 Conference on Retroviruses and Opportunistic Infections

HIVandHepatitis.com coverage of the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014), March 3-6, 2014, in Boston.

Conference highlights include new treatments for hepatitis C, HIV experimental therapies and treatment strategies, HIV cure research, HIV-related conditions, treatment as prevention and PrEP, and HIV/HCV coinfection.

Full listing by topic

Selected presentations and slide webcasts 

3/9/14

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CROI 2014: Chronic Lung Disease Is Prevalent and Under-diagnosed in People with HIV

Even though the incidence of most HIV-related respiratory complications and opportunistic infections have declined dramatically since the advent of effective antiretroviral therapy (ART), 4 studies presented at the 21st Conference on Retroviruses and Opportunistic Infections (CROI) last month in Boston showed that people living with HIV are still at increased risk of serious progressive lung complications, including under-diagnosed chronic obstructive pulmonary disease (COPD) and emphysema.

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Coverage of the 2014 Conference on Retroviruses and Opportunistic Infections

HIVandHepatitis.com coverage of the 21st Conference on Retroviruses and Opportunistic infections (CROI 2014), March 3-6, 2014, in Boston.

Conference highlights include new treatments for hepatitis C, HIV experimental therapies and treatment strategies, HIV cure research, HIV-related conditions, treatment as prevention and PrEP, and HIV/HCV coinfection.

Full HIVandHepatitis.com coverage by topic

Selected presentations and slide webcasts 

3/9/14

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CROI 2014: Vitamin D and Rosuvastatin Improve Bone Loss in People with HIV

A combination of high-dose vitamin D and calcium may help reduce bone loss after starting antiretroviral therapy (ART), according to a presentation at the Conference on Retroviruses and Opportunistic Infections (CROI 2014) last month in Boston. A related study found that rosuvastatin increased hip bone mineral density in HIV positive people on ART, though insulin resistance worsened.

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CROI 2014: Depression and HIV are Risk Factors for Heart Failure Among Veterans

Both HIV infection and depression are independent risk factors for incident heart failure, and living with both HIV and depression multiplies the risk, according to an analysis of data from the Veterans Aging Cohort Study presented at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston.

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CROI 2014: Neurocognitive Problems, Depression, and Early ART in People with HIV

In a particularly challenging area of HIV care where research is complicated by gaps in knowledge and invasive clinical procedures, there was significant attention to neurological manifestations -- or neuroAIDS -- at this year’s Conference on Antiretroviral Agents and Chemotherapy (CROI 2014) last month in Boston.

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CROI 2014: Tesamorelin Growth-Hormone Releaser Reduces Liver Fat in People with HIV

Tesamorelin, a synthetic form of growth-hormone-releasing hormone (GHRH), which the FDA has approved to reduce excess visceral abdominal fat in people living with HIV, also reduced associated liver fat in an HIV positive cohort chosen for abdominal adiposity, according to the results from a randomized, placebo-controlled trial presented at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston.

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CROI 2014: Researchers Discuss HIV, Aging, and Frailty

People living with HIV are at greater risk of geriatric syndromes such as frailty and difficulty with daily activities than HIV negative people of the same age -- and this can have a significant effect upon their quality of life as they age, according to several studies presented at the 14th Conference on Retroviruses and Opportunistic Infections (CROI 2014) last month in Boston.

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CROI 2014: Retrovirus Conference Now Underway in Boston

The 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) kicked off in Boston this week with a program for young investigators, a press conference on new hepatitis C treatments, and opening lectures on HIV immune response and cross-species transmission and an update on the epidemic in West Africa.

HIVandHepatitis.com will be on site all week bringing you the latest news.alt

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Men with HIV Have Higher Risk of Heart Disease

HIV positive men have more extensive atherosclerosis, or build-up of plaque in their arteries, than HIV negative men after taking into account other cardiovascular risk factors, potentially raising the risk of heart attack, according to an analysis from the large MACS cohort published in the April 1 Annals of Internal Medicine.

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CROI 2014: The Role of Interferon in HIV Response [VIDEO]

Although interferon is on its way out as a standard of care for hepatitis C, researchers are learning more about its role in HIV, conference vice chair Julie Overbaugh said at a media briefing on the opening day of the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston.

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