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HIV-Related Conditions

IDWeek 2014: Acute Retroviral Syndrome Linked to Higher HIV Levels in Blood, Gut and Brain

People with acute or very recent HIV infection who experience the flu-like symptoms of acute retroviral syndrome (ARS) have higher levels of HIV RNA and proviral DNA in their blood, colon, and brain tissue, indicating more active viral replication, as well as higher levels of certain inflammatory biomarkers researchers reported at IDWeek 2014 this month in Philadelphia.

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HIVMA Issues Guidelines for Managing Chronic Kidney Disease in People with HIV

The HIV Medical Association (HIVMA) of the Infectious Diseases Society of America (IDSA) has released updated recommendations for HIV positive people with chronic kidney disease. The guidelines, published in the September 17 issue of Clinical Infectious Diseases, state that antiretroviral therapy (ART) is beneficial for such patients, but they should avoid tenofovir (Viread, also in the Truvada, Atripla, Complera, and Stribild coformulations), which can cause kidney impairment.

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Rilpivirine Is Associated with Less Blood Fat Elevation than Efavirenz

People with HIV who started first-line treatment with a regimen containing rilpivirine (Edurant, also in the Complera coformulation) had smaller blood lipid increases and were less likely to have abnormal levels than those who started on efavirenz (Sustiva, also in the Atripla coformulation), according to 2-year data from the ECHO and THRIVE trials published in the April 11 online edition of Clinical Infectious Diseases.

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ICAAC 2014: New Drug Isavuconazole Is Effective Against Opportunistic Fungal Infections

A new antifungal drug, isavuconazole, matched the efficacy of voriconazole for treatment of invasive fungal infections in cancer patients with compromised immunity, but with fewer side effects, researchers reported at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy last week in Washington, DC.Isavuconazole was shown to be effective against various fungal infections that act as opportunistic illnesses in people with HIV/AIDS, including Aspergillus, Candida, and Cryptococcus.

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People with HIV Have Higher Bone Fracture Risk in Danish Study

Being HIV positive was associated with a nearly 3-fold greater likelihood of bone fractures overall -- and a 9-fold higher risk of hip and spine fractures -- compared with HIV negative people, according to results from a large Danish population study described in the May 1 Journal of Acquired Immune Deficiency Syndromes.

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AIDS 2014: COPD Is Common Among People with HIV Even At High CD4 Counts

Chronic obstructive pulmonary disease (COPD) is not uncommon among HIV positive adults with CD4 counts above 500 cells/mm3 -- that is, even fairly early in the course of infection -- according to the first findings from a pulmonary substudy of the large international Strategic Timing of Antiretroviral Treatment (START) trial, presented At the 20th International AIDS Conference last month in Melbourne. Among the nearly 1000 participants with good quality spirometry (pulmonary function) tests, the overall COPD prevalence was 6.8%, but there was considerable variation across regions.

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People with HIV Have Higher Risk of Melanoma Skin Cancer

People with HIV -- especially those with light skin -- continue to have a significantly increased risk of developing melanoma in the era of highly effective antiretroviral therapy, and should protect themselves from the sun, according to a meta-analysis published in the April 16 edition of the open-access journal PLoS ONE.

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AIDS2014: Efavirenz Use Not Linked to Neurocognitive Impairment, Study Finds

People who use antiretroviral regimens containing efavirenz (Sustiva, also in the Atripla coformulation) were not at higher risk for impaired neurocognitive function, either overall or when looking at specific functional domain, researchers reported this week at the 20th International AIDS Conference in Melbourne, Australia.

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CROI 2014: Chronic Lung Disease Is Prevalent and Under-diagnosed in People with HIV

Even though the incidence of most HIV-related respiratory complications and opportunistic infections have declined dramatically since the advent of effective antiretroviral therapy (ART), 4 studies presented at the 21st Conference on Retroviruses and Opportunistic Infections (CROI) last month in Boston showed that people living with HIV are still at increased risk of serious progressive lung complications, including under-diagnosed chronic obstructive pulmonary disease (COPD) and emphysema.

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AIDS 2014: Weight Gain on ART May Raise Risk of Heart Disease and Diabetes

People with HIV who gain weight shortly after starting antiretroviral therapy (ART) may have an increased risk of cardiovascular disease and diabetes, according to findings from the D:A:D study presented this week at the 20th International AIDS Conference in Melbourne, Australia.

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CROI 2014: Vitamin D and Rosuvastatin Improve Bone Loss in People with HIV

A combination of high-dose vitamin D and calcium may help reduce bone loss after starting antiretroviral therapy (ART), according to a presentation at the Conference on Retroviruses and Opportunistic Infections (CROI 2014) last month in Boston. A related study found that rosuvastatin increased hip bone mineral density in HIV positive people on ART, though insulin resistance worsened.

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Coverage of the 2014 International AIDS Conference

HIVandHepatitis.com coverage of the 20th International AIDS Conference (AIDS 2014), July 20-25, in Melbourne, Australia.

Conference highlights include biomedical HIV prevention (PrEP and treatment-as-prevention), HIV cure research, interferon-free therapy for hepatitis C and HIV/HCV coinfection, access to treatment, and fighting stigma and criminalization of key affected populations.

Full listing by topic

AIDS 2014 website

7/25/14

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CROI 2014: Neurocognitive Problems, Depression, and Early ART in People with HIV

In a particularly challenging area of HIV care where research is complicated by gaps in knowledge and invasive clinical procedures, there was significant attention to neurological manifestations -- or neuroAIDS -- at this year’s Conference on Antiretroviral Agents and Chemotherapy (CROI 2014) last month in Boston.

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AIDS 2014: Anal Lesions Often Resolve Without Treatment In HIV Positive Gay Men

High-grade anal dysplasia is common among gay men living with HIV, but it often resolves spontaneously and routine treatment may not be beneficial, according to results from the Australian SPANC study presented this week at the 20th International AIDS Conference in Melbourne.

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CROI 2014: Researchers Discuss HIV, Aging, and Frailty

People living with HIV are at greater risk of geriatric syndromes such as frailty and difficulty with daily activities than HIV negative people of the same age -- and this can have a significant effect upon their quality of life as they age, according to several studies presented at the 14th Conference on Retroviruses and Opportunistic Infections (CROI 2014) last month in Boston.

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ASCO: Characteristics and Disparities of Care for HIV+ People with Lung Cancer

HIV positive people with lung cancer are diagnosed at a younger age and have shorter survival than HIV negative people, on average, suggesting that screening should perhaps be started earlier, according to studies presented at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO) this month in Chicago.

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Men with HIV Have Higher Risk of Heart Disease

HIV positive men have more extensive atherosclerosis, or build-up of plaque in their arteries, than HIV negative men after taking into account other cardiovascular risk factors, potentially raising the risk of heart attack, according to an analysis from the large MACS cohort published in the April 1 Annals of Internal Medicine.

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People with HIV Are at Higher Risk for Cancers Linked to Smoking, Viruses

People with HIV appeared to have a higher overall rate of cancer in a large Danish study, but the difference was only significant for malignancies caused by smoking or other viruses, including lung cancer, anal cancer, and liver cancer. A related U.S. study found the rate of prostate cancer was actually lower among HIV positive men.

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CROI 2014: Heart Attack Link to Abacavir Persists in D:A:D Study

The nucleoside reverse transcriptase inhibitor abacavir (Ziagen, also in Epzicom or Kivexa) continues to be associated with a near-doubling of the risk of heart attack, according to the latest update from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) study, presented to the 21st Conference on Retroviruses and Opportunistic Infections (CROI) this month in Boston.

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ASCO: HCV Reactivation, Brain Involvement Do Not Worsen Lymphoma Survival for People with HIV

Reactivation of hepatitis C was common among HIV positive people with lymphoma, but did not appear to lead to worse outcomes or decreased survival, according to a study presented at the 50th American Society of Clinical Oncology (ASCO) meeting this week in Chicago. A related study found that having central nervous system involvement at the time of diagnosis did not decrease survival of people with AIDS-related lymphoma.

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CROI 2014: Newborns Exposed to Tenofovir Have Lower Bone Content [VIDEO]

Infants born to women who took tenofovir during pregnancy had significantly lower bone mineral content than babies who were not exposed, according to study findings reported at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this month in Boston.

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