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Updated Hepatitis C Care and Treatment Guidelines Published in Hepatology

The latest updated U.S. recommendations for hepatitis C testing, management, and treatment, compiled by an expert panel of members of the American Association for the Study of Liver Diseases (AASLD) and partner organizations, have been published in the June 25 advance online edition of Hepatology, the AASLD's professional journal.

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Hepatitis C Rising -- Especially Among Young People -- and May Be Underestimated

The Centers for Disease Control and Prevention (CDC) Division of Viral Hepatitis has released its 2013 Viral Hepatitis Surveillance Report, providing the latest data on hepatitis A, B, and C in the U.S. While hepatitis C has traditionally been predominant among Baby Boomers, the new report shows that HCV incidence is rising fastest among young people. But a recently published related study suggests that formal surveillance methods may grossly underestimate the number of people newly infected with HCV.

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ASCO 2015: Does Hepatocellular Carcinoma Differ in People with Hepatitis B and C?

Liver cancer patients with hepatitis B at a large U.S. cancer center appeared to have worse disease status than those with hepatitis C, including larger tumors and more extensive liver involvement, according to research presented at the American Society of Clinical Oncology (ASCO) annual meeting this month in Chicago. Prognosis for the 2 groups was similar, however.

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Adding Ribavirin to Harvoni for Hepatitis C Increases Side Effects But Not Efficacy

Combining sofosbuvir/ledipasvir (Harvoni) with ribavirin was associated with a greater likelihood of adverse events and laboratory abnormalities, but did not significantly increase the chances of sustained response for genotype 1 chronic hepatitis patients compared to sofosbuvir/ledipasvir alone, according to an analysis of the Phase 3 ION trials described in the July edition of Hepatology.

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EASL 2015: Hepatitis C Treatment Could Cut HCV Transmission Among UK Gay Men in Half

Access to more effective hepatitis C treatment could reduce new infections among men who have sex with men in the United Kingdom by half over the next decade, according to a mathematical modeling study presented at the European Association for the Study of the Liver (EASL) International Liver Congress in Vienna in April.

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Viekira Pak Regimen Cures 100% of Genotype 1b Hepatitis C Patients with Cirrhosis

All participants in the TURQUOISE-III trial, which enrolled HCV genotype 1b patients with compensated liver cirrhosis, achieved sustained virological response using AbbVie's Viekira Pak or "3D" regimen without ribavirin, according to a company announcement this week.

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Merck Submits Grazoprevir/ Elbasvir for FDA Approval, BMS Gets Breakthrough Status for Daclatasvir

Merck has requested U.S. Food and Drug Administration (FDA) approval for its promising grazoprevir/elbasvir coformulation for people with hepatitis C virus genotypes 1, 4, or 6, the company recently announced. In related news, Bristol-Myers Squibb said that the FDA has granted Breakthrough Therapy status for daclatasvir plus sofosbuvir for people with advanced cirrhosis and liver transplant recipients.

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Liver Transplants in HIV/HCV Coinfection: Study Underlines Importance of Hepatitis C Treatment

People with HIV and hepatitis C virus (HCV) coinfection were significantly more likely to experience organ rejection than people with either hepatitis C alone or HIV alone after undergoing a liver transplant, according to a review of 11 years of experience with liver transplantation in people with HIV and with hepatitis C in the U.S., published in the June 16 advance edition of the journal Clinical Infectious Diseases.

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EASL 2015: Reinfection after HCV Cure - Long-term Support Needed for People Who Have Injected Drugs

Reinfection rates after a hepatitis C cure among people who inject drugs, as well as past drug users, are relatively low, according to findings from studies from Norway and Canada presented at the European Association for the Study of the Liver (EASL) 50th International Liver Congress in Vienna in April. The findings suggest that current and former injection drug users who have been cured of hepatitis C require ongoing support to remain free of HCV, but also indicate that fears of a high rate of reinfection should not be used as a reason to withhold hepatitis C treatment from people who inject drugs.

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