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IDWeek 2014: Acute Retroviral Syndrome Linked to Higher HIV Levels in Blood, Gut and Brain

People with acute or very recent HIV infection who experience the flu-like symptoms of acute retroviral syndrome (ARS) have higher levels of HIV RNA and proviral DNA in their blood, colon, and brain tissue, indicating more active viral replication, as well as higher levels of certain inflammatory biomarkers researchers reported at IDWeek 2014 this month in Philadelphia.

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HIVMA Issues Guidelines for Managing Chronic Kidney Disease in People with HIV

The HIV Medical Association (HIVMA) of the Infectious Diseases Society of America (IDSA) has released updated recommendations for HIV positive people with chronic kidney disease. The guidelines, published in the September 17 issue of Clinical Infectious Diseases, state that antiretroviral therapy (ART) is beneficial for such patients, but they should avoid tenofovir (Viread, also in the Truvada, Atripla, Complera, and Stribild coformulations), which can cause kidney impairment.

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AIDS 2014: Weight Gain on ART May Raise Risk of Heart Disease and Diabetes

People with HIV who gain weight shortly after starting antiretroviral therapy (ART) may have an increased risk of cardiovascular disease and diabetes, according to findings from the D:A:D study presented this week at the 20th International AIDS Conference in Melbourne, Australia.

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ICAAC 2014: New Drug Isavuconazole Is Effective Against Opportunistic Fungal Infections

A new antifungal drug, isavuconazole, matched the efficacy of voriconazole for treatment of invasive fungal infections in cancer patients with compromised immunity, but with fewer side effects, researchers reported at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy last week in Washington, DC.Isavuconazole was shown to be effective against various fungal infections that act as opportunistic illnesses in people with HIV/AIDS, including Aspergillus, Candida, and Cryptococcus.

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Coverage of the 2014 International AIDS Conference

HIVandHepatitis.com coverage of the 20th International AIDS Conference (AIDS 2014), July 20-25, in Melbourne, Australia.

Conference highlights include biomedical HIV prevention (PrEP and treatment-as-prevention), HIV cure research, interferon-free therapy for hepatitis C and HIV/HCV coinfection, access to treatment, and fighting stigma and criminalization of key affected populations.

Full listing by topic

AIDS 2014 website

7/25/14

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AIDS 2014: COPD Is Common Among People with HIV Even At High CD4 Counts

Chronic obstructive pulmonary disease (COPD) is not uncommon among HIV positive adults with CD4 counts above 500 cells/mm3 -- that is, even fairly early in the course of infection -- according to the first findings from a pulmonary substudy of the large international Strategic Timing of Antiretroviral Treatment (START) trial, presented At the 20th International AIDS Conference last month in Melbourne. Among the nearly 1000 participants with good quality spirometry (pulmonary function) tests, the overall COPD prevalence was 6.8%, but there was considerable variation across regions.

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AIDS 2014: Anal Lesions Often Resolve Without Treatment In HIV Positive Gay Men

High-grade anal dysplasia is common among gay men living with HIV, but it often resolves spontaneously and routine treatment may not be beneficial, according to results from the Australian SPANC study presented this week at the 20th International AIDS Conference in Melbourne.

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AIDS2014: Efavirenz Use Not Linked to Neurocognitive Impairment, Study Finds

People who use antiretroviral regimens containing efavirenz (Sustiva, also in the Atripla coformulation) were not at higher risk for impaired neurocognitive function, either overall or when looking at specific functional domain, researchers reported this week at the 20th International AIDS Conference in Melbourne, Australia.

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ASCO: Characteristics and Disparities of Care for HIV+ People with Lung Cancer

HIV positive people with lung cancer are diagnosed at a younger age and have shorter survival than HIV negative people, on average, suggesting that screening should perhaps be started earlier, according to studies presented at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO) this month in Chicago.

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