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Second Potentially Cured Baby Has HIV Relapse Soon After Stopping Treatment

An Italian child who started antiretroviral treatment soon after birth and had undetectable plasma viral load, no apparent HIV DNA, and tested HIV antibody negative nevertheless experienced viral rebound shortly after a treatment interruption, once again disappointing hopes for a cure, researchers reported in the October 4 edition of The Lancet.

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Monkey Transplant Study Rules Out Possible HIV Cure Mechanism

Macaque monkeys that received transplants of their own stem cells after undergoing intensive radiation that killed off their existing SHIV-infected immune cells experienced viral rebound soon after stopping antiretroviral drugs, indicating that pre-transplant "conditioning" was not solely responsible for the only known case of a person cured of HIV.

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Mississippi Baby and Other Relapsers Hold Lessons for HIV Cure

Despite the disappointment felt by many, the return of detectable HIV in the Mississippi Baby and 2 patients who received bone marrow transplants are of "enormous scientific importance" and indicate that addressing the latent viral reservoir is the major challenge in achieving a cure or long-term remission, according to an editorial in the August 29 edition of Science.

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ICAAC 2014: Sangamo Provides Update on Gene Therapy to Protect T-cells From HIV

Several people with HIV whose CD4 T-cells were modified to make them resistant to viral entry have maintain low-level viral load after interrupting antiretroviral therapy (ART), with 1 individual having HIV RNA <1000 copies/mL for more than a year, according to a presentation at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy this week in Washington, DC.

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AIDS 2014: Australian Bone Marrow Transplant Patients Show No Detectable HIV

An additional 2 people with long-term HIV infection have no evidence of infectious virus or viral genetic material following bone marrow stem cell transplants to treat leukemia or lymphoma, researchers reported at the 20th International AIDS Conference last month in Melbourne. While these individuals remain on antiretroviral therapy (ART) and therefore cannot be considered functionally cured, they offer further evidence that HIV may be controlled off ART in some cases.

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