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Search for a Cure

Could a New Combination Treatment Strategy Eradicate HIV?

A new combination strategy could improve HIV treatment by destroying virus circulating in the body as well as HIV hiding in CD4 T-cells, according to a study published in the June 21, 2009 advance online issue of Nature Medicine

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HIV/AIDS Experts and Advocates Say Research Should Focus on a Cure

Effective combination antiretroviral therapy has dramatically reduced rates of illness and death among people with HIV, but it does not cure the disease. Recent research presented at the 16th Conference on Retroviruses and Opportunistic Infections (CROI 2009) last month in Montreal showed that even though today's best antiretroviral drugs can completely suppress viral replication, HIV remains in the body in resting CD4 T-cells and probably also in another as-yet unidentified "reservoir."

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ICAAC 2008: Zinc Finger Nuclease that Disables CCR5 Gene May Offer Potential New HIV Treatment Approach

It may be possible to create CD4 cells that are resistant to HIV infection by using zinc finger protein nucleases to disable the gene that encodes the CCR5 co-receptor, according to research presented at the 48th International Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2008) last month in Washington, DC.

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CROI 2009: Treatment Intensification with Raltegravir (Isentress) Does Not Eradicate Residual HIV

Effective combination antiretroviral therapy can reduce HIV viral load to an undetectable level in the blood using standard tests, but it does not completely eradicate the virus from the body. As Robert Siliciano of Johns Hopkins School of Medicine discussed in a plenary address at the 16th Conference on Retroviruses and Opportunistic Infections (CROI 2009) last month in Montreal, experts have long debated whether residual HIV is the result of continuing low-level viral replication or release of virus from stable reservoir sites.


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