HIV i-Base and TAG Release 2013 Pipeline Report on HIV, Hepatitis C, and TB Therapies

HIV i-Base and the Treatment Action Group (TAG) released their 2013 Pipeline Report this week in conjunction with the International AIDS Society conference (IAS 2013) in Kuala Lumpur. The guide provides the latest status of drugs, diagnostics, and candidate vaccines for HIV, hepatitis C, and tuberculosis.



Directly Observed Therapy for Tuberculosis No Better than Self-Administration

People who self-administered drugs to treat tuberculosis (TB) and those receiving directly observed therapy (DOT) had similar outcomes, according to a meta-analysis of 10 studies described in the July 2013 issue of Clinical Infectious Diseases


World TB Day: U.S. Cases Hit New Low, Integration with HIV Care Needed Worldwide

The number of new tuberculosis (TB) cases in the U.S. fell below 10,000 in 2012 -- the lowest rate since tallying began in the early 1950s, according to a Centers for Disease Control and Prevention(CDC) report released ahead of World TB Day on March 24. But the news is not all good, as novel treatments and better integration of care are needed on a global basis.

Vitamin C Rapidly Kills Drug-resistant Tuberculosis Bacteria

Vitamin C causes a chemical reaction that rapidly destroys Mycobacterium tuberculosis that is resistant to isoniazid and other drugs, researchers determined in a serendipitous discovery described in the May 21, 2013, edition of Nature Communications.


CROI 2013: Researchers Discuss Advances in Tuberculosis Treatment

A new two-drug combination of rifapentine and moxifloxacin can allow tuberculosis (TB) treatment to be taken just once-weekly during the 4-month continuation phase, according to a presentation at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) last week in Atlanta. A related meta-analysis found that rifampicin, a key drug in TB treatment, can be tolerated at much higher levels than used in current clinical practice, suggesting that higher doses might allow the treatment course to be shortened.