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Immune-Based Therapy GS-9620 Shows Promise for Hepatitis B

Gilead's GS-9620, an experimental TLR7 agonist, stimulated interferon production and activated B-cells and T-cells in laboratory and human studies, and was active against hepatitis B and a related virus in monkeys and woodchucks, researchers reported at EASL 2011.

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Telbivudine Label Adds Resistance Warning

Package labeling for the hepatitis B drug telbivudine (Tyzeka) was recently changed to add information about the risk of drug resistance and a recommendation for monitoring after 6 months of treatment.

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Entecavir Approved in Europe for Hepatitis B Patients with Decompensated Liver Diseases

Bristol-Myers Squibb announced early this month that the European Commission -- the regulatory authority for the European Union -- approved entecavir (Baraclude) for the treatment of hepatitis B virus (HBV) infection in patients with decompensated liver disease. The U.S. Food and Drug administration (FDA) granted similar approval this past October.

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Entecavir Beats Adefovir for Hepatitis B Treatment

A meta-analysis of 6 studies found that entecavir (Baraclude) was more effective than adefovir (Hepsera) for treatment-naive HBeAg positive Asian chronic hepatitis B patients. alt

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No Tenofovir Resistance after 3 Years among Chronic Hepatitis B Patients

Tenofovir (Viread) remains active against hepatitis B virus (HBV) and is not prone to drug-resistance mutations even after 3 years of treatment, according to study results published in the December 22, 2010 advance online edition of Hepatology. Further data presented at a recent liver disease conference indicate that this still remains the case after 4 years.

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