Coinfection

EACS 2017: Hepatitis C Halved among Spanish People with HIV Thanks to HCV Treatment

Spain is making dramatic progress towards eliminating hepatitis C among people living with HIV because of widespread use of direct-acting antivirals, Juan Berenguer of Hospital Gregorio Marañón in Madrid reported last week at the 16th European AIDS Conference (EACS 2017) in Milan.

[Produced in collaboration with aidsmap.com]

Sampling patients at 43 clinics in Spain, the researchers found that the proportion of people living with HIV who have chronic hepatitis C virus (HCV) coinfection has fallen dramatically since 2009, from approximately one-third of all patients in care to 12% of all patients in late 2016. In just one year, from late 2015 to late 2016, the prevalence of chronic hepatitis C among people living with HIV fell by 47%, from 22% to 12%.

The Spanish health care system has been providing direct-acting antiviral treatment for hepatitis C to everyone with moderate (stage F2) fibrosis or worse since early 2016 and provides treatment to anyone who might transmit HCV, regardless of fibrosis stage.

The GeSIDA Spanish researcher network carried out a cross-sectional study to evaluate the effect of improved hepatitis C treatment access on the prevalence of HCV coinfection among people with HIV in Spain. They sampled patients from 43 HIV treatment centers in proportion to their patient population, taking a random sample from each clinic. The total population in care was 38,904 in October and November 2016 (the sample period) and the random sample comprised 1588 patients, of whom 35% were men who have sex with men and 30% were people who had acquired HIV through injection drug use. This sample was compared with previous samples in 2002, 2009 and 2015.

Whereas 61% of those sampled had HCV antibodies in 2002, this proportion had declined to 35% by 2016. Similarly, the proportion with chronic HCV infection (HCV RNA positive) fell from 54% in 2002 to 34% in 2009 and to 12% in 2016.

In part, this can be explained by the declining proportion of the sample who had acquired HIV through injecting drug use -- 55% in 2002, and 30% in 2016 -- as this is a major route of HCV transmission.

However, the study also found that the proportion who had ever received hepatitis C treatment rose from 23% in 2002 to 48% in 2009, 59% in 2015, and to 75% in 2016. Of the 548 people who had HCV antibodies in the 2016 sample, 292 (53%) had been cured of hepatitis C. Of the remaining 186 people with chronic infection, 41 were undergoing treatment at the time of the survey, suggesting that if 95% of them were cured, HCV RNA prevalence could have been as low as 9%.

HCV Care Continuum Across Europe

Only half of people with diagnosed HIV/HCV coinfection in Southern Europe have ever started a course of treatment to cure hepatitis C, and less than 40% in Central and Eastern Europe have done so, an analysis of people receiving HIV care in the European region shows.

The findings, presented at EACS 2017 by Sarah Amele of University College London, come from the EuroSIDA study, an amalgamation of HIV treatment cohort studies in Western, Central, and Eastern Europe.

The study was designed to evaluate the continuum of hepatitis C care for people with HIV/HCV coinfection, from testing to treatment, who were in care in January 2015.

The researchers identified 6985 people in the EuroSIDA cohort with a positive HCV antibody test result prior to January 2015. Of these, 79% had a subsequent test for HCV RNA to diagnose chronic infection -- meaning that almost 1 in 5 did not receive a test to determine whether or not they had active HCV infection.

HCV RNA (also known as viral load) testing is an essential first step in determining whether a person with HCV antibodies is in need of treatment. People with HCV antibodies who have a negative HCV RNA test are presumed to have cleared the infection spontaneously.

HCV RNA testing occurred much less frequently in Eastern Europe than in Western Europe: only 46% received an HCV RNA test in Eastern Europe compared to 94% in Western Europe.

People from migrant communities were less likely to receive an HCV RNA test, but people who inject drugs were more likely to receive these tests than the population as a whole.

Of the entire population of people with HCV antibodies, 5027 had a positive HCV RNA test result and 57% of all people with HCV antibodies remained HCV RNA positive in January 2015. Of those who tested HCV RNA positive, 45% had an HCV genotype test.

Less than half (45%) of all those diagnosed with chronic infection had undergone any course of treatment by January 2015, and in the overwhelming majority of cases the treatment consisted of interferon and ribavirin. Only 9% received a course of interferon-free treatment with direct-acting antivirals.

Although 2079 people completed a course of treatment, the treatment outcome was documented for only 1305 people due to lack of virological testing during and after treatment. Just 285 people with chronic infection were cured of HCV in the period up to January 2015 -- approximately 5% of all those diagnosed with chronic infection.

Overall, the study found that a substantial proportion of people were being lost at each stage of the care continuum and that access to treatment remained poor for people living with HIV.

10/31/17

Sources

S Amele et al. The hepatitis C continuum of care among HIV-infected individuals in EuroSIDA. 16th European AIDS Conference. Milan, October 25-27, 2017. Abstract PS9/1.

J Berenguer et al. HIV/HCV coinfection in Spain: elimination is a stone’s throw away. 16th European AIDS Conference. Milan, October 25-27, 2017. Abstract PS9/3, 2017.