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AASLD 2015: Liver Fibrosis Improves after Successful Treatment for Chronic Hepatitis C

A majority of chronic hepatitis C patients with advanced fibrosis or cirrhosis showed improvement in liver health following treatment, according to study findings presented at the 2015 AASLD Liver Meeting this week in San Francisco. However, the researchers identified few demographic, laboratory, or disease-related factors that could predict who would experience fibrosis regression and who would have worsening liver damage.

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AASLD 2015: People with Cirrhosis Cured of Hepatitis C Still Have Elevated Liver Cancer Risk

The burden of liver cancer and cirrhosis caused by hepatitis C virus (HCV) is likely to continue to grow in the U.S. despite curative treatment, and people who have cirrhosis at the time they are cured of hepatitis C will require long-term monitoring for liver cancer, studies presented this week at the AASLD Liver Meeting in San Francisco show.

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IAS 2015: Fibrosis Regression Linked to Reduced Complications and Death in HIV/HCV Coinfected

HIV/HCV coinfected people with cirrhosis who achieve sustained virological response (SVR) and experience an improvement in liver fibrosis are less likely to develop liver disease complications or die from liver-related causes -- and in some cases fibrosis regression is beneficial even in the absence of a cure -- according to a presentation at the 8th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention last week in Vancouver. A related study looked at predictors of liver fibrosis progression in HIV/HCV coinfected people, finding that use of certain NRTI "backbone"' antiretroviral drugs and HIV protease inhibitors may increase the risk.

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Hepatitis C Cure Associated with Improvement in Liver Fibrosis in People with HIV/HCV Coinfection

A successful response to hepatitis C virus (HCV) therapy is associated with a significant improvement in liver stiffness among people with HIV and HCV coinfection, French investigators report in the September 10 online edition of AIDS.

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DDW 2015: Cirrhosis and Decompensation Are Common Among People with Chronic Hepatitis C

More than one-quarter of Kaiser-Permanente chronic hepatitis C patients developed cirrhosis over 12 years and 40% of these experienced decompensation -- rates higher than expected, according to a presentation at the recent Digestive Disease Week 2015 meeting in Washington, DC. The study also found that cirrhosis and decompensation were associated with comorbid conditions, supporting the idea of hepatitis C as a systemic disease.

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