CROI: Researchers Report Further Findings from iPrEx PrEP Trial
- Details
- Category: Pre-exposure Prophylaxis (PrEP)
- Published on Monday, 07 March 2011 20:49
- Written by Paul Dalton
Investigators presented further details of findings from the ground-breaking iPrEx trial this week at the 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) in Boston. With longer follow-up, pre-exposure prophylaxis (PrEP) using tenofovir/emtricitabine (Truvada) continued to have a protective effect against HIV acquisition, but signs of mild bone loss raise potential concerns about safety.
CROI: New Tenofovir Pro-drug GS-7340 Looks Good in Early Study
- Details
- Category: Experimental HIV Drugs
- Published on Thursday, 10 March 2011 16:00
- Written by Paul Dalton
A new pro-drug formulation of tenofovir (currently marketed as Viread, also in the Truvada and Atripla combination pills) produces a higher drug concentration in lymphoid tissues that harbor HIV, offering the prospect of lower doses and new fixed-dose formulations, according to a presentation last week at the 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) in Boston. Further studies are needed to determine whether higher tenofovir concentrations will lead to worse bone or kidney toxicity. 
CROI: HCV Protease Inhibitor Boceprevir Improves Response for Treatment-Naive and Non-responders
- Details
- Category: Experimental HCV Drugs
- Published on Tuesday, 15 March 2011 12:37
- Written by Liz Highleyman
Merck's investigational hepatitis C virus (HCV) protease inhibitor boceprevir improved sustained response rates when combined with pegylated interferon plus ribavirin in both previously untreated patients and those who were non-responders or relapsers after prior therapy, according to 2 Phase 3 studies presented at the 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) this month in Boston. 
CROI: Experimental Integrase Inhibitor Dolutegravir Looks Promising for People with Resistant HIV
- Details
- Category: Experimental HIV Drugs
- Published on Tuesday, 15 March 2011 05:53
- Written by Liz Highleyman
The second-generation integrase inhibitor dolutegravir (formerly known as S/GSK1349572 or simply GSK572) demonstrated potent activity with a favorable tolerability profile for HIV patients with highly resistant virus in the second cohort of the VIKING study, researchers reported at the 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) this month in Boston. Results indicate that the drug works better when taken twice rather than once daily.
CROI: Studies Shed Further Light on Cardiovascular Disease among People with HIV
- Details
- Category: Cardiovascular Disease
- Published on Friday, 18 March 2011 00:00
- Written by Paul Dalton
HIV positive people are at higher risk for cardiovascular disease overall, compared with HIV negative individuals, according to findings from Kaiser Permanente presented this month at the 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011). Other studies found that HIV positive people on ART with well-preserved immune function were not at greater risk, however, and that abacavir (Ziagen) was not linked to heart attacks.
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