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Neurocognitive Problems

Function Imaging Changes May Reflect Brain Impairment during Early HIV Infection

Functional magnetic resonance imaging during the early stages of HIV disease reveals changes in connectivity in the brain that may be due to high-level viral replication soon after infection, according to a study in the September 20, 2011, issue of Brain Connectivity. Researchers suggested this method may be useful as a non-invasive marker for future neurocognitive impairment.

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IAS 2011: Cognitive Impairment is Common, but ART Reduces Risk

Cognitive impairment remains common among people with HIV and is linked to more severe immune deficiency and absence of treatment, researchers reported at the International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2011) this week in Rome. But drugs that penetrate the central nervous system do not appear to improve overall outcomes. alt

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Lowest-ever CD4 Count Predicts Cognitive Impairment

Low nadir CD4 T-cell count before starting antiretroviral treatment raises risk of neurocognitive problems for people with HIV. 

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Damage to Blood-Brain Barrier May Explain Neurocognitive Problems

HIV weakens the blood-brain barrier, which may help explain low-level cognitive impairment in people with HIV despite effective antiretroviral treatment.

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CROI 2011: HIV Enters and Injures Brain Early

Structure and function changes in the brain are evident early in the course of HIV infection and are linked to inflammation, researchers reported at CROI 2011.


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