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Cardiovascular Disease

IAS 2011: Coronary Artery Calcification Linked to Bone Loss

Coronary artery calcification is associated with and low femoral bone mineral density (BMD), but no such link found with lumbar spine BMD, researchers reported at IAS 2011 in Rome.

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Abacavir Looks as Safe and Effective as Tenofovir

A meta-analysis of 28 controlled trials did not find elevated heart attack risk with abacavir, and a Canadian study showed no greater risk of treatment failure among patients with high viral load, according to 2 recently published reports.

The association between use of abacavir (Ziagen, also in the Epzicom and Trizivir coformulations) and myocardial infarction (MI), or heart attack, remains controversial, as does the suggestion that abacavir may not work as well for people who start antiretroviral therapy (ART) with high HIV viral load.

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Do HIV+ People Have Higher Stroke Risk?

A Danish study finds HIV positive people have a higher risk for stroke, increasing with injection drug use and lower CD4 cell count but not antiretroviral therapy overall.

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Triglycerides Contribute to Higher HIV+ Heart Attack

Higher triglycerides were marginally associated with increased risk of myocardial infarction in the large D:A:D trial, but the effect was small after taking into account cholesterol and other cardiovascular disease risk factors.

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Niaspan + Statin Does Not Reduce Heart Attack Risk

The large AIM-HIGH trial showed that extended-release niacin (Niaspan) plus simvastatin (Zocor) raised HDL cholesterol and lowered triglycerides, but the combo did not decrease the likelihood of heart attacks and may have increased the risk of strokes.

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